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Aaron B. Simon, MD, PhD

Aaron B. Simon, MD, PhDAssistant Professor

Dr. Aaron Simon is an Assistant Professor and Chief of the Central Nervous System service in the Department of Radiation Oncology at UCI. Dr. Simon is a graduate of Brown University where he earned a Bachelor of Science degree in Biophysics. He then subsequently earned a Medical Degree and Ph.D. in Bioengineering from the University of California, San Diego. His residency training was completed at the University of California, San Diego where he was awarded grants and accolades for his research in function imaging and stereotactic radiotherapy.

Dr. Simon specializes in the management of malignant and benign tumors of the brain and spinal cord and also has an interest in the treatment of skin cancers and soft tissue sarcomas. As an expert in the use of radiosurgery, Dr. Simon is actively involved in investigational studies to improve the efficacy and safety of radiation therapy for brain tumors. His research interests involve the incorporation of advanced, quantitative imaging techniques into the specialty of radiation oncology. Dr. Simon has received prestigious grants from the Radiological Society of North America (RSNA) and the American Society for Clinical Oncology (ASCO) for his translational research.



  • University of California, San Diego, 2021


  • University of California, Davis, Sacramento, CA, 2017


  • MD, University of California, San Diego, San Diego, CA, 2016
  • PhD, Bioengineering, University of California, San Diego, San Diego, CA, 2014

Certifications and Memberships

  • American Board of Radiology, Radiation Oncology
  • NCI Quantitative Imaging in Radiation Therapy
  • American Society of Clinical Oncology
  • American Board of Radiology
  • American Society for Radiation Oncology


  • RSNA Roentgen Resident/Fellow Research Award
  • ACRO Annual Meeting Best Award
  • Merck Award for Outstanding Academic Accomplishment, UCSD

Selected Publications

  1. Simon AB, Hurt B, Karunamuni R, Kim G, Moiseenko V, Olson S, Farid N, Hsiao A, Hattangadi-Gluth J. Automated segmentation of multiparametric magnetic resonance images for cerebral AVM radiosurgery planning: a deep learning approach. Sci Rep 2022; 12(1): 786.
  2. Saddawi-Konefka R, O'Farrell A, Faraji F, Clubb L, Allevato MM, Jensen SM, Yung BS, Wang Z, Wu VH, Anang NA, Msari RA, Schokrpur S, Pietryga IF, Molinolo AA, Mesirov JP, Simon AB, Fox BA, Bui JD, Sharabi A, Cohen EEW, Califano JA, Gutkind JS. Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC. Nat Commun 2022. 13(1): 4298.
  3. Saddawi-Konefka R, Simon AB, Sumner W, Sharabi A, Mell LK, Cohen E. Defining the role of immunotherapy in the curative treatment of locoregionally advanced head and neck cancer: promises, challenges, and opportunities. Front Oncol 2021; 11: 738626.
  4. Huynh-Le MP, Tibbs MD, Karunamuni R, Salans M, Tringale KR, Yip A, Connor M, Simon AB, Vitzthum LK, Reyes A, Macari AC, Moiseenko V, McDonald CR, Hattangadi-Gluth JA. Microstructural injury to corpus callosum and intrahemispheric white matter tracts correlate with attention and processing speed decline after brain radiation. Int J Radiat Oncol Biol Phys 2021; 110(2): 337-347.
  5. Srinivas S, Retson T, Simon AB, Hattangadi-Gluth J, Hsiao A, Farid N. Quantification of hemodynamics of cerebral arteriovenous malformations after stereotactic radiosurgery using 4D flow magnetic resonance imaging. J Magn Reson Imaging 2020; 53(6): 1841-1850.
  6. Tibbs MD, Huynh-Le MP, Karunamuni R, Reyes A, Macari AC, Tringale K, Salans M, Yip A, Liu E, Simon AB, et al. Microstructural injury to left-sided perisylvian white matter predicts language decline after brain radiotherapy. Int J Radiat Oncol Biol Phys 2020. 108(5): 1218-1228.
  7. Simon AB, Mell LK. To intensify or not to intensify? Consideration of competing risks in the management of locoregionally advanced p16+ oropharyngeal cancer. Int J Radiat Oncol Biol Phys 2020; 107(4): 613-614.
  8. Simon AB, Vitzthum LK, Mell LK. Challenge of directly comparing imaging-based diagnoses made by machine learning algorithms with those made by human clinicians. J Clin Oncol 2020; 38(16): 1868-1869.

Office LocationContact Us

Department of Radiation Oncology

UCI Medical Center

  • UCI Chao Family Comprehensive Cancer Center

    101 The City Drive, Bldg. 23, Orange
    CA 92868-3298
    Fax: (714) 456-7170
  • UCI Health
  • UC Irvine Health School of Medicine
  • University of California Irvine